Search on: GUANYLYL IMIDODIPHOSPHATE 
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Descriptor English:   Guanylyl Imidodiphosphate 
Descriptor Spanish:   Guanilil Imidodifosfato 
Descriptor Portuguese:   Guanilil Imidodifosfato 
Synonyms English:   GMP-P(NH)P
Gpp(NH)p
Guanosine 5'-(Beta,Gamma-Imido)Triphosphate
Guanyl-5'-Imidodiphosphate
P(NH)PPG
Guanyl 5' Imidodiphosphate
Imidodiphosphate, Guanylyl
GMP-PNP  
Tree Number:   D03.633.100.759.646.454.504.400
D13.695.667.454.504.400
D13.695.827.426.504.400
Definition English:   A non-hydrolyzable analog of GTP, in which the oxygen atom bridging the beta to the gamma phosphate is replaced by a nitrogen atom. It binds tightly to G-protein in the presence of Mg2+. The nucleotide is a potent stimulator of ADENYLYL CYCLASES. 
Indexing Annotation English:   DF: GPPNHP
History Note English:   91(78); was see under GUANOSINE TRIPHOSPHATE 1978-90 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
EC economics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UR urine
Record Number:   6315 
Unique Identifier:   D006165 

Occurrence in VHL:
 

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